Microcrystalline Cellulose [trade name: Avicel 101, 102, 200; Celex, MCC Sanaq], Powdered Cellulose [5–40% for wet granulation and 10–30% for dry granulation], Mannitol [preferable for chewable tablet], Compressible Sugar (20–60% for chewable tablets), Ethyl Acrylate and Methyl Methacrylate Copolymer Dispersion, Magnesium Carbonate (direct compression ≤45), Methacrylic Acid and Ethyl Acrylate Copolymer, Methacrylic Acid and Methyl Methacrylate Copolymer. Polysorbate 80 in tablet formulations containing starch, had elicited faster drug dissolution rates despite the prolonged disintegration. Regulations, Guidelines and Clinical Trials, Problems Encountered During Trituration and Possible Solutions, Mechanisms Involved in the Mixing of Pharmaceutical Powders, Mixing of Pharmaceutical Powders in Small-Scale Operations, Advancements in Pharmaceutical Suspensions and Their Patents, Manufacture of Pharmaceutical Suspensions, Major components of Softgel Encapsulating Machine, Major Differences between Prokaryotic and Eukaryotic Cells, Advantages and Disadvantages of Medicated Chewing Gum, Recent Advances in Granulation Technology for Pharmaceutical Formulations, Common Defects in Film Coating Process: Causes and Possible Solutions, Top 10 Pharmaceutical Companies in the World, National Agency for Food & Drugs Admin & Control, Journal of Pharmaceutical Development and Industrial Pharmacy, To mask the bitter taste and unpleasant odour of some drugs, To improve product appearance for aesthetic or commercial purposes (aiding in brand identification). Sweetening agents are the chemical substances that added to either mask the unpleasant taste or …, Your email address will not be published. Tablet coating is the outer covering of a tablet with a layer/substance. All Rights Reserved . To facilitate handling, particularly in high-speed packaging/filling lines, and automated counters in pharmacies, where the coating minimizes cross-contamination due to dust elimination. The United States Pharmacopeia. Here, compendial means the excipient is indexed in the pharmacopoeia. The substance used to coat tablets or particles. Tablets to be coated should normally be compressed with deep concave punches and die sets. A disintegrant is a substance or a mixture of substances added to a tablet to facilitate its breakup or disintegration into small units/fragments and allow a drug substance to fast dissolution. Calcium Alginate & Calcium Sodium Alginate (<10%), Calcium carboxymethylcellulose / calcium cellulose glycolate / carmellosum calcium (1–15%), Colloidal Silicon Dioxide (trade name: Aerosil 200/ Cab-o-sil), Ethyl Maltol (It has a flavor and odor 4–6 times as intense as maltol), Film formers, which may be enteric or non-enteric, Miscellaneous coating solution components. Have you ever chewed on a tablet and had an explosion of bitter regret in your mouth? Other reasons to provide better tablet properties such as to provide improved cohesion, improve flow, allow direct compression manufacturing, and adjust tablet thickness or weight. They are vital excipients for modified-release tablets. The process may sometimes result in various coating defects like chipping, cracking etc. Your email address will not be published. (2014). Read more on sugar coating of pharmaceutical tablets. Types and Functionality of Tablet Coating. the stomach for non-steroidal anti-inflammatory drugs (NSAIDs). Compression coating. According to USP, Tablet and capsule binders are substances that incorporated into formulations to facilitate the agglomeration of powder into granules during mixing with a granulating fluid such as water, hydroalcoholic mixtures, or other solvents [3]. Release-modifying agents are substances used as an excipient to control drug release in a modified-release dosage form such as in prolonged-release or controlled-release tablets. The most important note is the only diluent is adjusted with the total quantity of active after potency calculation. fragrance) response when orally consumed or smelled [3]. ©2020 PharmaEducation, All Rights Reserved, Characteristics of ideal excipients for tablets, Common Excipients for tablets Manufacturing, List of Binder used in Pharmaceutical Preparations, List of Disintegrants used in pharmaceutical preparations, List of lubricants used in pharmaceutical solid dosage form, List of glidant used in pharmaceutical solid dosage form, List of coloring agents used in a pharmaceutical solid dosage form such as tablets, List of Flavoring agent used in pharmaceutical solid dosage form, List of sweetening agent used in tablet and other pharmaceutical products, List of Release-Modifying Agents used in tablets. There are several types of tablet coating machines currently in the market. Over the course of time, coating processes have developed from the art of earlier years to those that are more technologically advanced and controlled such that compliance with good manufacturing practices (GMPs) is facilitated. Read more on quality control tests for tablets. To prevent drug-induced irritation at a specific site within the gastrointestinal tract, e.g.